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<p>In this study, we aimed to assess the factors that predict a dysfunctional conditioned pain modulation (CPM) in chronic knee OA.&nbsp;</p>
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<p><strong>Methods:</strong>&nbsp;This is a cross-sectional analysis of patients with chronic knee OA from a prospective cohort study in Brazil (n = 85). We performed linear and logistic multivariate regression models using the purposeful selection approach to test the relationship between the CPM in both knees (average) as a dependent variable and demographics, clinical, and neurophysiological as independent variables.&nbsp;</p>
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<p><strong>Results:</strong>&nbsp;A significant negative association between WOMAC pain scores and CPM (β: -0.13) was found. This association was modified by the subjects' race, being stronger in the non-white subjects. In our logistic regression models, pain intensity indexed with the WOMAC pain scale remained a significant association with dichotomized CPM. Furthermore, a significant CPM association with balance, indexed with the Berg Balance score, was evidenced (β: 0.04). Neurophysiological variables showed a significant negative relationship with CPM, such as the relative power of delta oscillations in the frontal area (β: -3.11) and central area (β: -3.23). There was no significant relationship between CPM and the following domains: cognitive, emotion, sleep, opioid receptor polymorphisms, and intrinsic variables of OA disease. There was no association of CPM with TMS-indexed inhibitory markers.&nbsp;</p>
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<p><strong>Conclusions:</strong>&nbsp;These results may indicate that less function of the pain descending inhibitory system in patients with OA is correlated with higher activity-related pain (WOMAC), less balance, and cortical plasticity especially with increased low-frequency (delta) brain oscillations. These associations seem modified by race.</p>
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<p>Autoria:<br><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Simis+M&amp;cauthor_id=37629554">Marcel Simis</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Pacheco-Barrios+K&amp;cauthor_id=37629554">Kevin Pacheco-Barrios</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Vasquez-Avila+K&amp;cauthor_id=37629554">Karen Vasquez-Avila</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Rebello-Sanchez+I&amp;cauthor_id=37629554">Ingrid Rebello-Sanchez</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Parente+J&amp;cauthor_id=37629554">Joao Parente</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Castelo-Branco+L&amp;cauthor_id=37629554">Luis Castelo-Branco</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Marduy+A&amp;cauthor_id=37629554">Anna Marduy</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=de+Melo+PS&amp;cauthor_id=37629554">Paulo S de Melo</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Imamura+M&amp;cauthor_id=37629554">Marta Imamura</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Battistella+L&amp;cauthor_id=37629554">Linamara Battistella</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Fregni+F&amp;cauthor_id=37629554">Felipe Fregni</a><sup>&nbsp;</sup></p>
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