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<p>Knee osteoarthritis (KOA) is a prevalent condition, and its most frequent symptom is pain that often leads to disability. Pain sensitization is a core feature of KOA, and it can be measured through quantitative sensory testing protocols such as pain pressure threshold (PPT). However, there is a lack of understanding about the factors that may influence changes in PPTs in the KOA population.</p>
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<p><strong>Objective:&nbsp;</strong>To explore the clinical and functional factors associated with PPTs in a sample of people with chronic KOA pain and to compare models of local (knees) and remote (thenar regions) sites.</p>
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<p><strong>Design:&nbsp;</strong>Cross-sectional analysis of a prospective cohort.</p>
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<p><strong>Setting:&nbsp;</strong>Primary care in public institution.</p>
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<p><strong>Participants:&nbsp;</strong>113 adults with KOA.</p>
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<p><strong>Main outcome measures:&nbsp;</strong>Multivariable regression analyses evaluating demographic, clinical, and functional variables that could be associated with local and remote PPTs (main outcomes) were performed.</p>
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<p><strong>Results:&nbsp;</strong>Both thenar region (adjusted-R<sup>2</sup>&nbsp;: 0.29) and knee (adjusted-R<sup>2</sup>&nbsp;: 0.45) models had the same significant negative association with being a female, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain levels (thenar: β: -0.15, p = .002; knee: β: -0.2, p &lt; .001), and the 10-Meter Walking Test (thenar: β: -0.05, p = .038; knee: β: -0.08, p = .004). A small significant positive association with depressive symptoms was identified in both models, which acted as a confounder for WOMAC pain and was likely affected by unmeasured confounders.</p>
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<p><strong>Conclusions:&nbsp;</strong>PPTs in KOA pain are associated with functional outcomes such as the 10-Meter Walking Test and activity-related pain intensity; thus more disability is associated with smaller pain thresholds. Similarity between models may suggest central sensitization.</p>
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<p>Autoria:<br><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Imamura+M&amp;cauthor_id=37455395">Marta Imamura</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Rebello-Sanchez+I&amp;cauthor_id=37455395">Ingrid Rebello-Sanchez</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Parente+J&amp;cauthor_id=37455395">Joao Parente</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Marduy+A&amp;cauthor_id=37455395">Anna Marduy</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Vasquez-Avila+K&amp;cauthor_id=37455395">Karen Vasquez-Avila</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Pacheco-Barrios+K&amp;cauthor_id=37455395">Kevin Pacheco-Barrios</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Castelo-Branco+L&amp;cauthor_id=37455395">Luis Castelo-Branco</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Simis+M&amp;cauthor_id=37455395">Marcel Simis</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Battistella+L&amp;cauthor_id=37455395">Linamara Battistella</a>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Fregni+F&amp;cauthor_id=37455395">Felipe Fregni</a></p>
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<p id="copyright">© 2023 American Academy of Physical Medicine and Rehabilitation.</p>
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