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<p>Non-invasive sound wave brain stimulation with Transcranial Pulse Stimulation (TPS) improves neuropsychiatric symptoms in Alzheimer's disease</p>
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<p>Methods:&nbsp;In a prospective, one-arm open-label trial, ten patients with mild to moderate dementia due to AD were assessed using the Alzheimer's Disease Assessment Scale (ADAS-Cog), Neuropsychiatric Inventory (NPI), Pfeffer Functional Activities Questionnaire, and Zarit Caregiver Burden Interview. Assessments occurred at 30- and 90-days post-treatment. The TPS protocol consisted of 10 sessions over five weeks, using the Neurolith® device to deliver 6000 focused shockwave pulses at 0.25 mJ/mm2 and a frequency of 4 Hz.</p>
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<p>Results:&nbsp;TPS significantly reduced neuropsychiatric symptoms, with NPI scores decreasing by 23.9 points (95% CI: -39.19 to -8.61, p = 0.0042) after 30 days, and by 18.9 points (95% CI: -33.49 to -2.91, p = 0.022) after 90 days. These changes had large effect sizes (Cohen's dz = 1.43 and dz = 0.94, respectively). A decreasing trend was observed in the ADAS-Cog score (-3.6, 95% CI: -7.18 to 0.00, p = 0.05) after 90 days, indicating a potential reduction in cognitive impairment, though not statistically significant.</p>
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<p>Conclusion:&nbsp;The preliminary results indicate that TPS treatment leads to significant improvement in neuropsychiatric symptoms in AD patients, showing promise as a therapeutic approach for AD. Further research is needed to fully establish its effectiveness, especially concerning cognitive functions.</p>
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<p>Autoria:<br><a href="https://pubmed.ncbi.nlm.nih.gov/?term=Shinzato+GT&amp;cauthor_id=38513821">Gilson Tanaka Shinzato</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Assone+T&amp;cauthor_id=38513821">Tatiane Assone</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Sandler+PC&amp;cauthor_id=38513821">Paulo C Sandler</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Pacheco-Barrios+K&amp;cauthor_id=38513821">Kevin Pacheco-Barrios</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Fregni+F&amp;cauthor_id=38513821">Felipe Fregni</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Radanovic+M&amp;cauthor_id=38513821">Marcia Radanovic</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Forlenza+OV&amp;cauthor_id=38513821">Orestes Vicente Forlenza</a><sup>&nbsp;</sup>,&nbsp;<a href="https://pubmed.ncbi.nlm.nih.gov/?term=Battistella+LR&amp;cauthor_id=38513821">Linamara Rizzo Battistella</a><sup>&nbsp;</sup></p>
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